Saltillo is a borough in Huntingdon County, Pennsylvania, United States. The population was 343 at the 2000 census.HistorySaltillo was named after the Mexican War Battle of Saltillo (23 October 1840). It was a major tanning center during the late 18th and early 19th century. The Leas and McVitty Tannery was located here, a tannery known for quality hides. The main line of the East Broad Top Railroad and Coal Company was built through Saltillo in 1874. The railroad serviced the tannery as well as a short lived iron mine and an equally short lived limestone quarry, both just southeast of town. Saltillo was an important place on the EBT acting as a base station for the long grade up to Broad Top Mountain. The EBT had a three track yard, a station, a water tank and a turning wye located here. Just after the turn of the 20th century a large Ganister quarry was established above Saltillo on Jacks Mountain by Mount Union Refractories (later United States Refractories and North American Refractories) to supply their plant in Mount Union, Pennsylvania. In 1942 a spur was built from the EBT yard in Saltillo which climbed the mountain to a tipple below the quarry. The branch was the steepest track on the EBT and remained in service until the line closed in 1956. The quarry continued to operate into the 1970s, serviced by trucks. Saltillo was also the location of a grist mill which still exists at the southwest edge of town.The EBT tracks on Saltillo are still in place. The water tank was burned by vandals in the late 1980s and the station was demolished in the mid-2000s after being allowed to deteriorate to deplorable condition.